Deson PR Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Action Indications/Uses Dosage/Direction for Use Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Metformin

Indications/Uses

Management of type 2 DM (NIDDM) when hyperglycemia cannot be managed w/ diet & exercise alone.

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Dosage/Direction for Use

Initially 1 tab once daily. Max: 1,500-2,000 mg once daily.

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Administration

Should be taken with food: Take w/ evening meal. Swallow whole w/ full glass of water. Do not chew/crush/break.

Contraindications

Hypersensitivity. Renal disease or renal dysfunction, abnormal CrCl; acute or chronic metabolic acidosis w/ or w/o coma (including diabetic ketoacidosis).

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Special Precautions

Renal impairment. Lactic acidosis. Discontinue in clinical situations predisposing hypoxemia, including eg, CV collapse, resp failure, acute MI, acute CHF & septicemia; temporarily discontinue prior to or at the time of intravascular administration of iodinated contrast media. Patients w/ CHF particularly unstable or acute CHF. Withhold in patients w/ dehydration &/or prerenal azotemia & 48 hr after radiologic study. Suspend therapy for any surgical procedure. Consider to discontinue therapy if exposed to stress (fever, trauma, infection, surgery) & administer insulin instead. Avoid excessive ethanol use. Increased CV mortality is possible. Elderly ≥80 yr. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Diarrhea, nausea/vomiting, flatulence; weakness. Chest discomfort, flushing, palpitation; headache, chills, dizziness, lightheadedness; rash; hypoglycemia; indigestion, abdominal discomfort, abdominal distention, abnormal stools, constipation, dyspepsia/heartburn, taste disorder; myalgia, URTI; decreased vit B₁₂ levels, increased diaphoresis, flu-like syndrome, nail disorder; lactic acidosis, leukocytoclastic vasculitis, megaloblastic anemia, pneumonitis.

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Drug Interactions

Increased effect/toxicity w/ cephalexin, cimetidine, iodinated contrast agents & pegvisomant. Decreased effect w/ corticosteroids, LH-releasing hormone analogs, somatropin & thiazide drugs. Hypoglycemia may occur w/ ethanol, chromium, garlic, gymnema. May decrease absorption of vit B₁₂ &/or folic acid.

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Storage

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Action

View Deson PR mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Antidiabetic Agents

ATC Classification

A10BA02 - metformin ; Belongs to the class of biguanides. Used in the treatment of diabetes.

Thai FDA Category

Presentation/Packing

Form

Deson PR XR tab 1,000 mg

Packing/Price

10 × 10's

Form

Deson PR XR tab 750 mg

Packing/Price

10 × 10's

Deson PR

metformin

Manufacturer:

Unison

Distributor:

Medline

Marketer:

Medline